Oral Presentation (max 20 mins including Q&A) National Men's Health Gathering 2025

Lifting depression the science behind exercise and brain health in men (129276)

Jesse O'Sullivan 1
  1. Project U.P., VARSITY LAKES, QUEENSLAND, Australia

Despite increasing awareness of mental health, male suicide rates in Australia remain stubbornly high. While top-down interventions like counselling and medication have value, many men are still falling through the cracks. Emerging research highlights the power of bottom-up approaches—those targeting physiology first—to significantly shift mental health outcomes. Physical health strategies, particularly those that build structure, strength and self-efficacy, may provide a culturally-aligned way to engage men earlier and more effectively.
This presentation will explore the science behind how physical activity, strength training, cardiovascular conditioning, nutrition, sleep, and behavioural strategies can rewire brain function, regulate mood, and reduce depressive symptoms in men. The focus is on how these interventions can be integrated into the everyday lives of working-age men—particularly through technology, workplace wellness programs and a multidisciplinary team of health professionals.
Drawing on exercise physiology, neuroscience, and practical coaching experience with hundreds of men across Australia, this talk will outline a holistic, behaviour-first framework that puts action before introspection. We will discuss the physiological mechanisms by which exercise and lifestyle habits influence neurotransmitter regulation, neuroplasticity, and stress resilience. Case studies will demonstrate how embedding these interventions in daily life has led to improvements in both mental and physical health—especially when programs are designed with male psychology and workplace culture in mind.
Delegates will gain a renewed understanding of how body-first mental health strategies—particularly strength training—can complement traditional models and better engage men who may otherwise resist formal mental health support. Attendees will leave with actionable strategies and resources for implementing these approaches within their services, communities, or workplaces. This aligns with the Gathering’s goal to deliver practical, real-world innovations that reduce male suicide and strengthen the physical, emotional, and social wellbeing of men across Australia.