Oral Presentation (max 20 mins including Q&A) National Men's Health Gathering 2025

The silent crisis: generational testosterone decline and its impact on men’s mental and physical health (125732)

Saara H Jamieson 1
  1. Cool Beans Underwear, CHUWAR, QLD, Australia

Testosterone is often framed as the hormone of masculinity, but its role in men’s health is far broader and more vital than many realise. Emerging evidence shows a troubling generational decline in testosterone levels – with men today producing significantly less than their fathers and grandfathers. While this trend has been largely overlooked in mainstream conversations, it has profound implications for every aspect of men’s wellbeing – from fertility and physical health to mental resilience and longevity.

This presentation will explore how declining testosterone levels across generations have become a silent crisis, compounding physical and mental health challenges for men of all ages. Testosterone isn’t just about muscle and libido; it influences mood regulation, stress response, cognitive function, and overall vitality. Low testosterone has been directly linked to increased risk of depression, anxiety, and mood disorders, creating a cycle where physical decline fuels mental vulnerability, and vice versa.

As a medical researcher turned founder of Cool Beans Underwear – the world’s first and only TGA-registered testicular cooling and supporting medical device – I’ve seen firsthand how this issue intersects with modern life. Factors like prolonged sitting, restrictive clothing, and environmental heat exposure have only accelerated this decline, pushing men’s bodies into a constant state of thermal stress that suppresses natural testosterone production.

But it’s not just an athlete’s issue – it’s a health crisis that affects fathers, brothers, sons, and friends. And it’s one that starts younger than we think.

This session will:
• Highlight the clinical evidence and generational data on testosterone decline
• Explain how compounding testicular heat and environmental factors fuel this trend
• Explore the direct connections between low testosterone, mental health vulnerability, and recovery challenges
• Share practical, evidence-based strategies for reversing this decline and supporting long-term health

It’s time to broaden the conversation around men’s health beyond the gym and the bedroom. By understanding the deep connections between testosterone, mental health, and daily habits, we can create real solutions that empower men to live healthier, happier lives.

Together, let’s normalise these conversations and prioritise men’s physical and mental wellbeing – for this generation and the next.

  1. Zarrouf, F. A., Artz, S., Griffith, J., Sirbu, C., & Kommor, M. (2009). Testosterone and depression: Systematic review and meta-analysis. Journal of Psychiatric Practice, 15(4), 289–305. https://doi.org/10.1097/01.pra.0000358315.88931.fc
  2. Malkin, C. J., Pugh, P. J., Jones, R. D., Kapoor, D., Channer, K. S., & Jones, T. H. (2004). The effect of testosterone replacement on endogenous inflammatory cytokines and depressive symptoms in hypogonadal men. The Journal of Clinical Endocrinology & Metabolism, 89(7), 3313–3318. https://doi.org/10.1210/jc.2003-031069
  3. Corona, G., Rastrelli, G., Morgentaler, A., Sforza, A., Mannucci, E., & Maggi, M. (2014). Meta-analysis of results of testosterone therapy on sexual function based on International Index of Erectile Function scores. The Journal of Sexual Medicine, 11(6), 1577–1592. https://doi.org/10.1111/jsm.12537
  4. Walther, A., Mahler, F., Debelak, R., & Ehlert, U. (2017). Psychobiological protective factors modifying the association between low testosterone and depression in men. Psychoneuroendocrinology, 84, 46–52. https://doi.org/10.1016/j.psyneuen.2017.06.005
  5. Zarrouf, F. A. (2017). The impact of testosterone replacement therapy on depression and well-being: A systematic review. Primary Care Companion for CNS Disorders, 19(1). https://doi.org/10.4088/PCC.17r02077